Rat Anti-Mouse IL-1 receptor antagonist
Details
Gene name synonims
N/A
Concentration
N/A
Purification method
N/A
Immunoglobulin isotype
IgG2
Clone
(#5K21)
Category
Antibodies
Clonality
Monoclonal
Form/Appearance
Lyophilized
Gene name
IL-1 receptor
Tested applications:
Western Blot (WB)
Subcategory
Mnoclonal antibodies
Host organism
Rat (Rattus norvegicus)
Also known as
IL-1 receptor antagonist
Latin name
Mus musculus,Rattus norvegicus
Other gene names
Il1rn; Il1rn; IL-1ra; F630041P17Rik; Il-1ra; IL-1RN; IL-1ra; IRAP
Species reactivity
Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Specificity and cross-reactivity
N/A; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Other names
interleukin-1 receptor antagonist protein isoform 2; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL1 inhibitor; interleukin 1 receptor antagonist; IL1 inhibitor
About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Gene
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Rec. E. coli interleukin-1 for cell culture or antibody production.
Storage and shipping
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < Store the antibody at -20 degrees Celsius. for at least for six months without detectable loss of activity.
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Description
The antagonist receptor ligand binding will be in contrast with agonist activity. MBS Monoclonals produces more antagonist and receptor related products as 1.This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.