Details

Gene name synonims

N/A

Concentration

N/A

Purification method

N/A

 

Immunoglobulin isotype

IgG2

Clone

(#5K21)

Category

Antibodies

 

Clonality

Monoclonal

Form/Appearance

Lyophilized

Gene name

IL-1 receptor

 

Tested applications:

Western Blot (WB)

Subcategory

Mnoclonal antibodies

Host organism

Rat (Rattus norvegicus)

 

Also known as

IL-1 receptor antagonist

Latin name

Mus musculus,Rattus norvegicus

Other gene names

Il1rn; Il1rn; IL-1ra; F630041P17Rik; Il-1ra; IL-1RN; IL-1ra; IRAP

 

Species reactivity

Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Specificity and cross-reactivity

N/A; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Other names

interleukin-1 receptor antagonist protein isoform 2; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL1 inhibitor; interleukin 1 receptor antagonist; IL1 inhibitor

 

About

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Gene

The Interleukin-1 family (IL-1 family) is a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Rec. E. coli interleukin-1 for cell culture or antibody production.

Storage and shipping

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at

 

Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Description

The antagonist receptor ligand binding will be in contrast with agonist activity. MBS Monoclonals produces more antagonist and receptor related products as 1.This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.